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Article

Debrisoquine oxidation phenotype and neuroleptic-induced dystonic reactions.

Acta psychiatrica Scandinavica - 1 Nov 1992

Spina E, Sturiale V, Valvo S, Ancione M, Di Rosa A E, Meduri M, Caputi A P

Abstract excerpt

To evaluate the role of defective drug oxidation as a predisposing factor for neuroleptic-induced dystonic reactions, 26 patients who developed the reaction and 53 with no history of dystonia were phenotyped by the debrisoquine hydroxylation test. The percentage of poor debrisoquine metabolizers was similar in patients with dystonic reactions (11.5%) and in the control group (9.4%). These results suggest that...

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Identifiers

PMID: 1485526
DOI: 10.1111/j.1600-0447.1992.tb03281.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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