Debrisoquine oxidation phenotype and neuroleptic-induced dystonic reactions.

doi:10.1111/j.1600-0447.1992.tb03281.x

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Article

Debrisoquine oxidation phenotype and neuroleptic-induced dystonic reactions.

Acta psychiatrica Scandinavica - 1 Nov 1992

Spina E, Sturiale V, Valvo S, Ancione M, Di Rosa A E, Meduri M, Caputi A P

Abstract excerpt

To evaluate the role of defective drug oxidation as a predisposing factor for neuroleptic-induced dystonic reactions, 26 patients who developed the reaction and 53 with no history of dystonia were phenotyped by the debrisoquine hydroxylation test. The percentage of poor debrisoquine metabolizers...

Topics

Adult
Debrisoquin
Dystonia
Female
Humans
Male
Middle Aged
Oxidation-Reduction
Phenotype

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