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Article

Mechanisms of isoniazid-induced idiosyncratic liver injury: emerging role of mitochondrial stress.

Journal of gastroenterology and hepatology - 1 Apr 2014

Boelsterli Urs A, Lee Kang Kwang

Abstract excerpt

Idiosyncratic drug-induced liver injury (DILI) is a significant adverse effect of antitubercular therapy with isoniazid (INH). Although the drug has been used for many decades, the underlying mode of action (both patient-specific and drug-specific mechanisms) leading to DILI are poorly understood. Among the patient-specific determinants of susceptibility to INH-associated DILI, the importance of HLA genetic...

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Identifiers

PMID: 24783247
DOI: 10.1111/jgh.12516

Genes

NAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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