Article
In vitro and in vivo mammalian mutation assays support a nonmutagenic mechanism of carcinogenicity for hydrazine.
Environmental and molecular mutagenesis - 1 Jan 2021
Nicolette John, Murray Joel, Sonders Paul, Kondratiuk Alison, Crosby Meredith
Abstract excerpt
Hydrazine has been described as a mutagenic, probable human carcinogen. It is mutagenic in in vitro systems such as bacterial reverse mutation (Ames) tests and some yeast systems, as well as in in vivo systems with drosophila. It was shown to cause chromosome damage both in vitro and in vivo but was negative in some well-validated mammalian mutation systems such as CHO HPRT assays. Importantly, there is only one...
Topics
- Adenoma, Liver Cell
- Animals
- Biological Assay
- Carcinogens
- Cell Line
- Epithelial Cells
- Female
- Hydrazines
- Liver
- Liver Neoplasms
- Lung
- Mammals
- Mice
- Mice, Inbred C57BL
- Mutagenesis
- Mutagenicity Tests
- Mutagens
- Mutation