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Article

Signal sequence mutations disrupt feedback between secretion of an exported protein and its synthesis in E. coli.

Nature - 1 Jan 2000

Kumamoto C A, Oliver D B, Beckwith J

Abstract excerpt

Recent studies in a eukaryotic system indicate that a block in secretion can lead to a block in the translation of secretory proteins. This feedback on protein synthesis is thought to be a result of an interaction of the signal recognition particle with the signal sequences of nascent proteins. Genetic studies in the prokaryote Escherichia coli suggest that a complex secretion machinery and a similar feedback...

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PMID: 6371546
DOI: 10.1038/308863a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Signal sequence mutations disrupt feedback between secretion of an exported protein and its synthesis in E. coli.PMID 6371546Read ↗

Continued functioning of the secretory pathway is essential for ribosome synthesis.Semantic proximity Read ↗

Effect of OmpA signal peptide mutations on OmpA secretion, synthesis, and assembly.Semantic proximity Read ↗

A signal sequence is not required for protein export in prlA mutants of Escherichia coli.Semantic proximity Read ↗

Recognition of secretory proteins in Escherichia coli requires signals in addition to the signal sequence and slow folding.Semantic proximity Read ↗

Signal peptide mutants of Escherichia coli.Semantic proximity Read ↗

SRP samples nascent chains for the presence of signal sequences by interacting with ribosomes at a discrete step during translation elongation.Semantic proximity Read ↗

Mutations that affect the folding of ribose-binding protein selected as suppressors of a defect in export in Escherichia coli.Semantic proximity Read ↗

Critical regions of secM that control its translation and secretion and promote secretion-specific secA regulation.Semantic proximity Read ↗

Mutations in the Escherichia coli ribosomal protein L22 selectively suppress the expression of a secreted bacterial virulence factor.Semantic proximity Read ↗

Regulation of Escherichia coli secA by cellular protein secretion proficiency requires an intact gene X signal sequence and an active translocon.Semantic proximity Read ↗

Translation arrest of SecM is essential for the basal and regulated expression of SecA.Semantic proximity Read ↗

SecD and SecF facilitate protein export in Escherichia coli.Semantic proximity Read ↗

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