Signal sequence mutations disrupt feedback between secretion of an exported protein and its synthesis in E. coli.

doi:10.1038/308863a0

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Article

Signal sequence mutations disrupt feedback between secretion of an exported protein and its synthesis in E. coli.

Nature - 1 Jan 2000

Kumamoto C A, Oliver D B, Beckwith J

Abstract excerpt

Recent studies in a eukaryotic system indicate that a block in secretion can lead to a block in the translation of secretory proteins. This feedback on protein synthesis is thought to be a result of an interaction of the signal recognition particle with the signal sequences of nascent proteins. G...

Topics

ATP-Binding Cassette Transporters
Amino Acid Sequence
Carrier Proteins
Escherichia coli
Escherichia coli Proteins
Feedback
Genes
Genes, Bacterial
Maltose-Binding Proteins
Monosaccharide Transport Proteins
Mutation
Species Specificity

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