Article
Serum protease inhibitory capacity. (Recent knowledge on alpha 1-antitrypsin deficiency).
La Ricerca in clinica e in laboratorio - 1 Jan 2000
Massi G, Bruscalupi G, Auconi P
Abstract excerpt
The molecular structure and the serum levels of alpha 1-antitrypsin, the major antiprotease of human serum, are controlled by a series of codominant alleles at a single chromosomal locus, known as the Pi(protease-inhibitor) locus. The congenital deficiency of this inhibitor is known to be associated with the development of lung emphysema in early adulthood and chronic liver disease in childhood. Less frequent...
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