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Article

Effects of the protease inhibitor (Pi) polymorphism on alpha-1-antitrypsin concentration and elastase inhibitory capacity in human serum.

Annals of human biology - 1 Jan 2000

Oakeshott J G, Muir A, Clark P, Martin N G, Wilson S R, Whitfield J B

Abstract excerpt

The concentration of alpha-1-antitrypsin (AAT) and its elastase inhibitory capacity (EIC) have been investigated in vitro in sera from 1688 healthy Canberra blood donors typed for electrophoretic variants of the protease inhibitor (Pi) locus. Nine Pi alleles were recorded in the sample, of which M1 was found at a frequency of nearly 70% and the other eight were each at frequencies below 15%. As a class,...

Topics

Adolescent
Adult
Aged
Alleles
Australia
Female
Genetic Carrier Screening
Genotype
Homozygote
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pancreatic Elastase

Phenotype

Polymorphism, Genetic

Sex Factors

alpha 1-Antitrypsin

Source

Identifiers

PMID: 3872620
DOI: 10.1080/03014468500007641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-3872620-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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