Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin.

doi:10.1038/311678a0

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Article

Three-dimensional structure of an antigenic mutant of the influenza virus haemagglutinin.

Nature - 1 Jan 2000

Knossow M, Daniels R S, Douglas A R, Skehel J J, Wiley D C

Abstract excerpt

Antigenic variation in the haemagglutinin (HA) glycoprotein of influenza virus is associated with recurrent epidemics of respiratory disease in man (for review see ref. 1). We have examined the size of structural changes necessary to alter the antigenicity of HA by determining the three-dimension...

Topics

Amino Acid Sequence
Epitopes
Genetic Variation
Hemagglutination Inhibition Tests
Hydrogen Bonding
Influenza A virus
Models, Molecular
Mutation
Protein Conformation
Viral Envelope Proteins
Viral Matrix Proteins

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