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Structural Consequences of Antigenic Variants of Human A/H3N2 Influenza Viruses

19 Apr 2023

Abstract excerpt

The genetic basis of antigenic drift of human A/H3N2 influenza virus is crucial to understanding the constraints of influenza evolution and determinants of vaccine escape. Amino acid changes at only seven positions near the receptor binding site of the surface hemagglutinin protein have been shown to be responsible for the major antigenic changes for over forty years. Experimental structures of HA are now...

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PMID: 37112987
DOI: 10.3390/v15041008

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