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Article

Point mutations in AAUAAA and the poly (A) addition site: effects on the accuracy and efficiency of cleavage and polyadenylation in vitro.

Nucleic acids research - 11 Oct 1990

Sheets M D, Ogg S C, Wickens M P

Abstract excerpt

Three sequences in the vicinity of poly (A) addition sites are conserved among vertebrate mRNAs. We analyze the effects of single base changes in each position of AAUAAA and in the nucleotide to which poly (A) is added on 3' end formation in vitro. All 18 possible single base changes of the AAUAAA sequence greatly reduce addition of poly (A) to RNAs that end at the poly (A) addition site, and prevent cleavage of...

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Identifiers

PMID: 2170946
DOI: 10.1093/nar/18.19.5799
PMCID: PMC332317

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