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Article

Point mutations upstream of the yeast ADH2 poly(A) site significantly reduce the efficiency of 3'-end formation.

Molecular and cellular biology - 1 Apr 1991

Hyman L E, Seiler S H, Whoriskey J, Moore C L

Abstract excerpt

The sequences directing formation of mRNA 3' ends in Saccharomyces cerevisiae are not well defined. This is in contrast to the situation in higher eukaryotes in which the sequence AAUAAA is known to be crucial to proper 3'-end formation. The AAUAAA hexanucleotide is found upstream of the poly(A) site in some but not all yeast genes. One of these is the gene coding for alcohol dehydrogenase, ADH2. Deletion or a...

Topics

Alcohol Dehydrogenase
Base Sequence
Cloning, Molecular
Genes, Fungal
Molecular Sequence Data
Mutation
Poly A
RNA, Fungal
RNA, Messenger
Restriction Mapping
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 2005893
DOI: 10.1128/mcb.11.4.2004-2012.1991
PMCID: PMC359886

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2005893-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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