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Article

Developmental Changes in the Human Heavy Chain CDR3

1 Dec 2005

Abstract excerpt

The CDR3 of the Ig H chain (CDR3(H)) is significantly different in fetal and adult repertoires. To understand the mechanisms involved in the developmental changes in the CDR3(H) of Ig H chains, sets of nonproductive V(H)DJ(H) rearrangements obtained from fetal, full-term neonates and adult single B cells were analyzed and compared with the corresponding productive repertoires. Analysis of the nonproductive...

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Identifiers

PMID: 16301650
DOI: 10.4049/jimmunol.175.11.7425

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