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Article

Sequence requirements for nuclear location of simian virus 40 large-T antigen.

Nature - 1 Jan 2000

Kalderon D, Richardson W D, Markham A F, Smith A E

Abstract excerpt

A point mutation in the simian virus 40 large-T gene, which was generated by mixed oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a large-T antigen that was detected in the cytoplasm but not the nucleus of cells. Deletions within the surrounding sequence Lys-128Lys-Lys-Arg-Lys-Val-Glu also produce cytoplasmic large-T and define a region of the protein involved in nuclear...

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PMID: 6088992
DOI: 10.1038/311033a0

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