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Article

Sequence requirements for nuclear location of simian virus 40 large-T antigen.

Nature - 1 Jan 2000

Kalderon D, Richardson W D, Markham A F, Smith A E

Abstract excerpt

A point mutation in the simian virus 40 large-T gene, which was generated by mixed oligonucleotide mutagenesis and resulted in the conversion of Lys 128 to Thr, produced a large-T antigen that was detected in the cytoplasm but not the nucleus of cells. Deletions within the surrounding sequence Lys-128Lys-Lys-Arg-Lys-Val-Glu also produce cytoplasmic large-T and define a region of the protein involved in nuclear...

Topics

Animals
Antigens, Polyomavirus Transforming
Base Sequence
Cell Line
Cell Nucleus
Cell Transformation, Viral
DNA Replication
DNA Restriction Enzymes
Mutation
Nucleic Acid Hybridization
Plasmids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats

Simian virus 40

Viral Proteins

Source

Identifiers

PMID: 6088992
DOI: 10.1038/311033a0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6088992-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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