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Article

A hydrophobic protein sequence can override a nuclear localization signal independently of protein context.

Molecular and cellular biology - 1 Oct 1991

van Zee K, Appel F, Fanning E

Abstract excerpt

Simian virus 40 T antigen is specifically targeted to the nucleus by the signal Pro-Lys-Lys-128-Lys-Arg-Lys-Val. We have previously described the isolation of a simian virus 40 T-antigen mutant, 676FS, which retains a wild-type nuclear localization signal but fails to accumulate properly in the nucleus and interferes with the nuclear localization of heterologous proteins. Here we report that the hydrophobic...

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Identifiers

PMID: 1656223
DOI: 10.1128/mcb.11.10.5137-5146.1991
PMCID: PMC361531

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