Cocaine and succinylcholine sensitivity: a new caution.

Article

Cocaine and succinylcholine sensitivity: a new caution.

Anesthesia and analgesia - 1 Jan 2000

Jatlow P, Barash P G, Van Dyke C, Radding J, Byck R

Abstract excerpt

Cocaine was stable (93.6 +/- 5.0 (SD)% remaining after 120 minutes) when incubated in plasma from six patients with histories of succinylcholine sensitivity and low dibucaine numbers (phenotype A), but was rapidly hydrolyzed (40.6 +/- 6.6% remaining after 120 minutes) when incubated in plasma obt...

Topics

Anesthesia, Intravenous
Anesthesia, Local
Apnea
Cholinesterases
Cocaine
Dibucaine
Drug Hypersensitivity
Homozygote
Humans
Hydrolysis
Phenotype
Succinylcholine

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