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Article

Genetic determinants of dabigatran plasma levels and their relation to bleeding.

Circulation - 2 Apr 2013

Paré Guillaume, Eriksson Niclas, Lehr Thorsten, Connolly Stuart, Eikelboom John, Ezekowitz Michael D, Axelsson Tomas, Haertter Sebastian, Oldgren Jonas, Reilly Paul, Siegbahn Agneta, Syvanen Ann-Christine, Wadelius Claes, Wadelius Mia, Zimdahl-Gelling Heike, Yusuf Salim, Wallentin Lars

Abstract excerpt

BACKGROUND: Fixed-dose unmonitored treatment with dabigatran etexilate is effective and has a favorable safety profile in the prevention of stroke in atrial fibrillation patients compared with warfarin. We hypothesized that genetic variants could contribute to interindividual variability in blood concentrations of the active metabolite of dabigatran etexilate and influence the safety and efficacy of dabigatran....

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Source

Identifiers

PMID: 23467860
DOI: 10.1161/CIRCULATIONAHA.112.001233

Genes

CES1
ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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