Exome-wide association study of bleeding events in patients receiving direct oral anticoagulants.

doi:10.1177/00368504251398881

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Article

Exome-wide association study of bleeding events in patients receiving direct oral anticoagulants.

Science progress - 1 Jan 2025

Sychev Dmitry A, Buianova Anastasiia A, Abdullaev Sherzod P, Mirzaev Karin B, Belova Vera A, Shmitko Anna O, Cheranev Valery V, Suchalko Oleg N, Fedina Lyudmila V, Batyukina Svetlana V, Shatalova Natalia A, Bochkov Pavel O, Glagolev Sergey V, Rebrikov Denis V, Korostin Dmitriy O

Abstract excerpt

BackgroundDirect oral anticoagulants (DOACs) are first-line medications for stroke prevention in non-valvular atrial fibrillation (AF). However, variability in drug response poses risks of hemorrhagic or thromboembolic events.ObjectivesAlthough genetic influences on DOACs safety are increasingly recognized, robust evidence directly linking specific polymorphisms to bleeding risk remains limited.DesignMulti-center...

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Topics

Humans
Male
Female
Hemorrhage
Aged
Atrial Fibrillation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Pyrazoles

Pyridones

Polymorphism, Single Nucleotide

Anticoagulants

Case-Control Studies

Rivaroxaban

Middle Aged

Administration, Oral

Genome-Wide Association Study

Cytochrome P-450 CYP3A

Exome

Source

Open in PubMed Open full text

Identifiers

PMID: 41313269
DOI: 10.1177/00368504251398881
PMCID: PMC12663078

Genes

CYP3A4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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