Article
The Pharmacogenetic Variability Associated with the Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Healthy Chinese Subjects: A National Multicenter Exploratory Study.
Clinical therapeutics - 1 Apr 2024
Liu Zhiyan, Xie Qiufen, Zhao Xia, Tan Yunlong, Wang Wenping, Cao Yu, Wei Xiaohua, Mu Guangyan, Zhang Hanxu, Zhou Shuang, Wang Xiaobin, Cao Ying, Li Xin, Chen Song, Cao Duanwen, Cui Yimin, Xiang Qian
Abstract excerpt
PURPOSE: This study aimed to explore the pharmacogenetic variability associated with the pharmacokinetics (PK) and pharmacodynamics (PD) of rivaroxaban in healthy Chinese subjects. METHODS: This was a multicenter study that included 304 healthy adults aged 18 to 45 years with unknown genotypes. All participants were administered a single dose of rivaroxaban at 10 mg, 15 mg, or 20 mg. PK and PD parameters were...
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