Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of Genetic Variants With Rivaroxaban Pharmacokinetics and Pharmacodynamics and Hemorrhage Risk Factors in Patients With Venous Thromboembolism.

Journal of the American Heart Association - 17 Jun 2025

Li Hui, He Xiaoshuang, Guan Yingyun, Lu Qiuya, Fang Jie, Bian Xiaolan

Abstract excerpt

BACKGROUND: Rivaroxaban is a first-line agent for venous thromboembolism prophylaxis and treatment. However, its pharmacokinetics, pharmacodynamics, and bleeding risk exhibit significant interindividual variability. Known nongenetic factors alone cannot fully explain this variability, and the impact of genetic polymorphisms remains debated. METHODS: From December 29, 2021, to May 11, 2023, 310 patients with...

Topics

Join the communities discussing this publication.

Blood Coagulation
China
Cytochrome P-450 CYP3A
Hemorrhage
Pharmacogenomic Variants

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Assessment

Venous Thromboembolism

Source

Open in PubMed Open full text

Identifiers

PMID: 40470653
DOI: 10.1161/JAHA.124.040698
PMCID: PMC12229112

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of Genetic Variants With Rivaroxaban Pharmacokinetics and Pharmacodynamics and Hemorrhage Risk Factors in Patients With Venous Thromboembolism.PMID 40470653Read ↗

Genetic variants influenced the risk of bleeding and pharmacodynamics of rivaroxaban in patients with nonvalvular atrial fibrillation: A multicentre prospective cohort studySemantic proximity Read ↗

Effect of Gene Polymorphism on the Pharmacokinetics and Clinical Outcomes of Rivaroxaban: State-of-the-Art ReviewSemantic proximity Read ↗

Pharmacogenetics of Bleeding and Thromboembolic Events in Direct Oral Anticoagulant Users.Semantic proximity Read ↗

The Pharmacogenetic Variability Associated with the Pharmacokinetics and Pharmacodynamics of Rivaroxaban in Healthy Chinese Subjects: A National Multicenter Exploratory Study.Semantic proximity Read ↗

Genetic variations in relation to bleeding and pharmacodynamics of dabigatran in Chinese patients with nonvalvular atrial fibrillation: A nationwide multicentre prospective cohort study.Semantic proximity Read ↗

Genetic assessment of efficacy and safety profiles of coagulation cascade proteins identifies Factors II and XI as actionable anticoagulant targetsSemantic proximity Read ↗

The impact of ABCB1, CYP3A4/5 and ABCG2 gene polymorphisms on rivaroxaban trough concentrations and bleeding events in patients with non-valvular atrial fibrillationSemantic proximity Read ↗

Genetic risk factors for venous thromboembolism.Semantic proximity Read ↗

Prediction of Venous Thromboembolism Based on Clinical and Genetic FactorsSemantic proximity Read ↗

Bleeding Events Associated with Rivaroxaban Therapy in Naive Patients with Nonvalvular Atrial Fibrillation: A Longitudinal Study from a Genetic Perspective with INR Follow-Up.Semantic proximity Read ↗

Genetic determinants of apixaban plasma levels and their relationship to bleeding and thromboembolic eventsSemantic proximity Read ↗

Historical review: more than two decades understanding the genetic architecture of hemostasis and thrombosis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.