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Article

A genetic variant of hypoxia-inducible factor-1alpha is associated with adverse outcomes in acute kidney injury.

Kidney international - 1 Jun 2009

Kolyada Alexey Y, Tighiouart Hocine, Perianayagam Mary C, Liangos Orfeas, Madias Nicolaos E, Jaber Bertrand L

Abstract excerpt

Hypoxia-inducible factor-1alpha (HIF-1alpha) is a transcription factor that mediates many cellular responses to tissue hypoxia, a common feature of acute kidney injury (AKI). Here we studied 241 patients with AKI and determined the relationship to adverse outcome of a non-synonymous polymorphism in the coding region of the HIF-1alpha gene where a C to T substitution occurs at position +85 in exon 12, a change...

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Identifiers

PMID: 19279559
DOI: 10.1038/ki.2009.68
PMCID: PMC2872511

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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