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Article

Genetic evidence for CTSH as a potential therapeutic target in sepsis: A Mendelian randomization and colocalization study.

Medicine - 18 Sept 2026

Du Yangwen, Zhou Lingyao, Huang BoWen, Lu Feng, Jin Qin, Lin Guo

Abstract excerpt

This study aimed to systematically evaluate the potential causal relationship between plasma and cerebrospinal fluid protein levels and sepsis risk through the integration of Mendelian randomization (MR) analysis, external validation, and Bayesian colocalization analysis. It further sought to explore the genetic mechanisms of key proteins and their potential as drug targets. We performed two-sample MR to screen...

Read the complete abstract on PubMed

Topics

Humans
Sepsis
Mendelian Randomization Analysis
Bayes Theorem
Genetic Predisposition to Disease
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Protein Interaction Maps

Source

Open in PubMed Open full text

Identifiers

PMID: 42760658
DOI: 10.1097/MD.0000000000050487
PMCID: PMC13593309

Genes

CTSH
IL6R
OLFM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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