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Therapeutic Targets for Sepsis: Multicenter Proteome-Wide Analyses and Experimental Validation

3 Jun 2025

Abstract excerpt

High Resolution Image Download MS PowerPoint Slide Sepsis is a life-threatening condition with high mortality, underscoring the urgent need for effective therapeutic targets. We conducted a proteome-wide Mendelian randomization (MR) analysis using plasma protein data from the FinnGen, UKB-PPP, and deCODE cohorts to identify proteins causally associated with sepsis. The analysis included 16,074 cases and 363,227...

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Inflammation biomarkers and pathways
S100 Proteins and Annexins
Sepsis Diagnosis and Treatment

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40459852
DOI: 10.1021/acs.jproteome.5c00148

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