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Article

The devil is in the enhancer: decoding regulatory variation at the ZNF827 locus in SCAD.

Clinical science (London, England : 1979) - 14 Oct 2026

Soler Eric

Abstract excerpt

Genome-wide association studies have identified numerous susceptibility loci for spontaneous coronary artery dissection (SCAD), yet translating non-coding genetic associations into molecular mechanisms remains a major challenge. In the present issue, Liu et al. provide functional evidence linking the SCAD-associated variant rs13128814 at the ZNF827 locus to the regulation of a vascular smooth muscle cell...

Read the complete abstract on PubMed

Topics

Humans
Enhancer Elements, Genetic
Genetic Predisposition to Disease
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Animals

Polymorphism, Single Nucleotide

DNA-Binding Proteins

Source

Identifiers

PMID: 42757439
DOI: 10.1042/CS20261108

Genes

ZNF827

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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