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Article

Development and external validation of a clinical-genetic risk identification model for rheumatoid arthritis-associated interstitial lung disease.

Frontiers in immunology - 1 Jan 2026

Fan Wei, Bo Wei, Yu Xuanhua, Gao Xiaojuan, Huang Jinmei, Zhang Yi, Wu Shufan, Chen Xuyan, Lu Liangjing, Yin Hanlin

Abstract excerpt

Objective: This study aimed to develop and externally validate a clinical risk identification model for prevalent rheumatoid arthritis-associated interstitial lung disease (RA-ILD) using multicenter Chinese patient cohorts. We also evaluated the discriminative value of MUC5B polymorphisms (rs35705950 and rs868903) in a combined clinical-genetic model for this purpose. Methods: A multicenter, two-phase design was...

Read the complete abstract on PubMed

Topics

Humans

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Arthritis, Rheumatoid

Lung Diseases, Interstitial

Female

Male

Middle Aged

Genetic Predisposition to Disease

Risk Factors

Mucin-5B

Polymorphism, Single Nucleotide

ROC Curve

Genetic Risk Score

Aged

Retrospective Studies

Risk Assessment

Genotype

Source

Open in PubMed Open full text

Identifiers

PMID: 42756139
DOI: 10.3389/fimmu.2026.1885469
PMCID: PMC13582460

Genes

MUC5B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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