Article
Association of rare single-nucleotide variant MUC5B rs35705950 with interstitial lung disease in Japanese rheumatoid arthritis.
Rheumatology (Oxford, England) - 1 Dec 2025
Higuchi Takashi, Oka Shomi, Shimada Kota, Tsunoda Shinichiro, Ito Satoshi, Okamoto Akira, Fujimori Misuzu, Nakamura Tadashi, Katayama Masao, Suzuki Michita, Saisho Koichiro, Shinohara Satoshi, Matsui Toshihiro, Migita Kiyoshi, Nagaoka Shouhei, Tohma Shigeto, Furukawa Hiroshi
Abstract excerpt
OBJECTIVES: RA is sometimes complicated by interstitial lung disease (ILD) with a poor prognosis. A single-nucleotide variant (SNV) in MUC5B was associated with ILD in European RA patients. However, associations of this SNV were not found in Japanese RA patients, because its frequency in Japanese populations is very low. We investigated the associations of candidate SNVs including the MUC5B variant with ILD in...
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