Spatial Single-Cell Mapping of Transcriptional Differences Across Genetic Backgrounds in Mouse Brains

Abstract excerpt

Genetic variation can alter organ structure and, in turn, function. Comparative statistical analysis of organs across genetic backgrounds requires spatial, single-cell, atlas-scale data in replicates, which current technologies do not provide at scale. We introduce A tlas-scale T ranscriptome L ocalization using A ggregate S ignatures (ATLAS), a scalable tissue mapping method. ATLAS learns transcriptional sig...

Topics

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• High-Throughput Nucleotide Sequencing
• Hypothalamus
• Mesencephalon
• Neuropeptides
• Neurotransmitter Agents
• Rhombencephalon
• Single-Cell Gene Expression Analysis
• Transcriptome

Identifiers and source

Literature Corpus work

49543727-3d00-5e21-8939-9a555fd97bbf

DOI

10.1101/2024.10.08.617260