Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis.

Journal of translational medicine - 22 Jan 2025

Guo Hua, Gao Jinyang, Gong Liping, Wang Yanqing

Abstract excerpt

BACKGROUND: To elucidate the genetic and molecular mechanisms underlying psoriasis by employing an integrative multi-omics approach, using summary-data-based Mendelian randomization (SMR) to infer causal relationships among DNA methylation, gene expression, and protein levels in relation to psoriasis risk. METHODS: We conducted SMR analyses integrating genome-wide association study (GWAS) summary statistics with...

Read the complete abstract on PubMed

Topics

Psoriasis
Humans
Genome-Wide Association Study
Quantitative Trait Loci
DNA Methylation
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Causality

Polymorphism, Single Nucleotide

Gene Expression Regulation

Multiomics

Source

Open in PubMed Open full text

Identifiers

PMID: 39844246
DOI: 10.1186/s12967-025-06099-w
PMCID: PMC11752815

Genes

APOF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-omics analysis reveals novel causal pathways in psoriasis pathogenesis.PMID 39844246Read ↗

Integrated multi-omics strategies for identifying novel therapies in psoriasis.Semantic proximity Read ↗

Multi‑omics and their integration in psoriasis research (Review).Semantic proximity Read ↗

Multi-Omics analysis identified DNA methylation and miRNAs mediated gene regulatory networks in PsoriasisSemantic proximity Read ↗

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targetsSemantic proximity Read ↗

Disentangling the complexity of psoriasis in the post-genome-wide association era.Semantic proximity Read ↗

Integrative Analysis of Plasma Proteomics and Transcriptomics Reveals Potential Therapeutic Targets for PsoriasisSemantic proximity Read ↗

Transcriptomic meta-analysis in plaque psoriasis: an integrative bioinformatic approach to deciphering the genetic landscape and molecular pathwaysSemantic proximity Read ↗

Mendelian randomization reveals DNA methylation-related pyroptosis genes associated with psoriasis risk.Semantic proximity Read ↗

Mapping the Causal Landscape of Psoriasis: A Systematic Mendelian Randomization Evidence Synthesis and Development of the MR-PsO Atlas Platform.Semantic proximity Read ↗

A catalog of potential putative functional variants in psoriasis genome-wide association regions.Semantic proximity Read ↗

Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants.Semantic proximity Read ↗

Whole-exome SNP array identifies 15 new susceptibility loci for psoriasis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.