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Article

Rare Variants May Influence Disease Risk and Clinical Features in Sporadic Late-Onset Chinese Parkinson's Disease Patients.

International journal of molecular sciences - 26 Aug 2026

Ho Ryan Wui-Hang, Xiong Zewei, Lo Rachel Cheuk-Nam, Liu Huifang, Ho Philip Wing-Lok, Sham Pak-Chung, Ho Shu-Leong, Pang Shirley Yin-Yu

Abstract excerpt

Heritability in Parkinson's disease (PD) may be driven by rare variants (RVs), but genetic data for Chinese cohorts remain limited. We investigated the relationship between RVs and the risk and phenotype of PD by performing targeted exome sequencing of 29 PD candidate genes in 311 late-onset, sporadic Chinese PD patients and 699 local controls. A total of 174 RVs (that were likely deleterious using in silico...

Read the complete abstract on PubMed

Topics

Aged
Female
Humans
Male
Middle Aged
Age of Onset

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

China

Exome Sequencing

Genetic Association Studies

Genetic Predisposition to Disease

Genetic Variation

Parkinson Disease

Phenotype

Risk Factors

East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 42737551
DOI: 10.3390/ijms27177653
PMCID: PMC13566319

Genes

SCARB2
GBA1
SLC44A1
SYNJ1

Variants

Provenance

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