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Novel and reported variants in Parkinson's disease genes confer high disease burden among Indians.

Parkinsonism & related disorders - 1 Sept 2020

Kumar Sumeet, Yadav Navneesh, Pandey Sanjay, Muthane Uday B, Govindappa Shyla T, Abbas Masoom M, Behari Madhuri, Thelma B K

Abstract excerpt

BACKGROUND: Genetic heterogeneity in Parkinson's disease (PD) has been unambiguously reported across different populations. Assuming a higher genetic load, we tested variant burden in PD genes to an early onset PD cohort from India. METHODS: Whole exome sequencing was performed in 250 PD patients recruited following MDS-UPDRS criteria. The number of rare variants in the 20 known PD genes per exome were used to...

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Identifiers

PMID: 32707456
DOI: 10.1016/j.parkreldis.2020.07.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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