Genetic Liability to COPD and Periodontitis Risk: Integrative Genetic and Single-Cell Evidence Implicating Macrophage Reprogramming.

Abstract excerpt

Introduction: Chronic obstructive pulmonary disease (COPD) and periodontitis frequently coexist, but directionality and shared cellular mechanisms remain uncertain. We evaluated whether genetically proxied COPD liability is associated with periodontitis risk and explored candidate immune mechanisms. Methods: We performed two-sample Mendelian randomization (MR) and smoking-adjusted multivariable MR (MVMR),...

Topics

• Humans
• Pulmonary Disease, Chronic Obstructive
• Animals
• Genetic Predisposition to Disease
• Macrophages
• Risk Factors