Article

Integrated analysis of Single-cell RNA-seq,Mendelian randomization and eQTL reveals immune cell-related nomogram model and subtypes in periodontitis Running title: Immune Cell Subtypes and Nomogram Model in Periodontitis

2024-11-29

Abstract excerpt

<title>Abstract</title> <p>Background Periodontitis is a prevalent chronic inflammatory disease characterized by immune cell dysregulation and tissue destruction. This study integrates single-cell RNA sequencing (scRNA-seq), Mendelian randomization (MR), and expression quantitative trait loci (eQTL) analyses to uncover immune cell subtypes, causal genes, and develop a predictive nomogram model for periodontitis....

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ccd52211-b3b9-5e8c-b078-ed1e575fc288
DOI: 10.21203/rs.3.rs-5300947/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrated analysis of Single-cell RNA-seq,Mendelian randomization and eQTL reveals immune cell-related nomogram model and subtypes in periodontitis Running title: Immune Cell Subtypes and Nomogram Model in PeriodontitisDOI 10.21203/rs.3.rs-5300947/v1Read

Multi-Omics Integration Reveals the Genetic Mechanisms of Periodontitis and Predicts Therapeutic Drugs.Semantic proximity Read

Myeloid dendritic cells and periodontal disease association: integrated study of single-cell sequencing and Mendelian randomization analysis.Semantic proximity Read

Mendelian randomized integration of GEO and eQTL data revealed genes associated with periodontitisSemantic proximity Read

Deciphering Periodontitis: Host Mechanisms, Predictive Biomarkers, and Systemic Drivers for Precision PreventionSemantic proximity Read

Dissecting B/Plasma Cells in Periodontitis at Single-Cell/Bulk ResolutionSemantic proximity Read

Identification of immune cells and key genes related to periodontitisSemantic proximity Read

Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal careSemantic proximity Read

Integrated analysis of single-cell RNA-seq, bulk RNA-seq, Mendelian randomization, and eQTL reveals T cell-related nomogram model and subtype classification in rheumatoid arthritisSemantic proximity Read

Single-cell RNA-seq combined with bulk RNA-seq analysis identifies necroptosis-related genes as therapeutic targets for periodontitisSemantic proximity Read

Single-cell RNA sequencing identifies heterogeneous cell subtypes within gingival tissueSemantic proximity Read

The underlying molecular mechanisms and biomarkers between periodontitis and COVID- 19Semantic proximity Read

Expression of periodontitis susceptibility genes in human gingiva using single-cell RNA sequencing.Semantic proximity Read