Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Multi-Omics Integration Reveals the Genetic Mechanisms of Periodontitis and Predicts Therapeutic Drugs.

International dental journal - 1 Aug 2026

Cao Ruoyan, Xu Shuangshuang, Xiang Junhao, Qu Beilei, Zhuang Zichao, Chu Tengda

Abstract excerpt

BACKGROUND: Periodontitis is a chronic inflammatory disease driven by host immune dysregulation. However, the specific genetic regulatory mechanisms underlying this disease remain unclear. Identifying key molecular targets is crucial for precise therapeutic intervention. METHODS: This study integrated genome-wide association study (GWAS) summary statistics from the Gene-Lifestyle Interactions in Dental Endpoints...

Topics

Join the communities discussing this publication.

Genetic Predisposition to Disease
Genome-Wide Association Study
Molecular Docking Simulation
Multiomics
Periodontitis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantitative Trait Loci

Single-Cell Analysis

Single-Cell Gene Expression Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 42269280
DOI: 10.1016/j.identj.2026.109678
PMCID: PMC13273467

Genes

GNLY

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multi-Omics Integration Reveals the Genetic Mechanisms of Periodontitis and Predicts Therapeutic Drugs.PMID 42269280Read ↗

Integrated analysis of Single-cell RNA-seq,Mendelian randomization and eQTL reveals immune cell-related nomogram model and subtypes in periodontitis Running title: Immune Cell Subtypes and Nomogram Model in PeriodontitisSemantic proximity Read ↗

Deciphering Periodontitis: Host Mechanisms, Predictive Biomarkers, and Systemic Drivers for Precision PreventionSemantic proximity Read ↗

Genetic associations between circulating immune cells and periodontitis highlight the prospect of systemic immunoregulation in periodontal careSemantic proximity Read ↗

Mendelian randomized integration of GEO and eQTL data revealed genes associated with periodontitisSemantic proximity Read ↗

Genetically Supported Drug Targets and Dental Traits: A Mendelian Randomization Study.Semantic proximity Read ↗

Impact of periodontitis on type 2 diabetes: a bioinformatic analysisSemantic proximity Read ↗

Combined periodontitis GWAS identifies LINC01541 as a regulator of innate immunity in the oral mucosa.Semantic proximity Read ↗

Expression of periodontitis susceptibility genes in human gingiva using single-cell RNA sequencing.Semantic proximity Read ↗

Identification of Novel Genome-Wide Associations for Oral Inflammatory TraitsSemantic proximity Read ↗

Causal effects of circulating inflammatory proteins on oral phenotypes: Deciphering immune-mediated profiles in the host-oral axis.Semantic proximity Read ↗

Myeloid dendritic cells and periodontal disease association: integrated study of single-cell sequencing and Mendelian randomization analysis.Semantic proximity Read ↗

Genetic Loci Associated With Periodontitis: The FinnGen Study Based on National Health Registers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.