Towards a Standard Threshold for Genome Wide Significance in Dogs.

Abstract excerpt

Genome-wide association studies (GWAS) are a foundational step in tying phenotype to genotype, relying on statistical significance thresholds to distinguish true- from false-positive signals of association. Dog genomics has long relied on per-study Bonferroni thresholds of significance, basing these on SNP chip levels of markers (~100 k to > 14 M variable sites). However, as the field progresses into whole genome...

Topics

• Animals
• Dogs
• Genome-Wide Association Study
• Polymorphism, Single Nucleotide
• Gene Frequency
• Breeding
• Haplotypes