Article
Efficient mapping of mendelian traits in dogs through genome-wide association.
Nature genetics - 1 Nov 2007
Karlsson Elinor K, Baranowska Izabella, Wade Claire M, Salmon Hillbertz Nicolette H C, Zody Michael C, Anderson Nathan, Biagi Tara M, Patterson Nick, Pielberg Gerli Rosengren, Kulbokas Edward J, Comstock Kenine E, Keller Evan T, Mesirov Jill P, von Euler Henrik, Kämpe Olle, Hedhammar Ake, Lander Eric S, Andersson Göran, Andersson Leif, Lindblad-Toh Kerstin
Abstract excerpt
With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with approximately 27,000 SNPs and show that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only approximately 20 dogs. Specifically, we map two traits with mendelian inheritance: the major...
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