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Article

DNA hypomethylation of the OLFM1 gene in patients with depression.

Frontiers in neurology - 1 Jan 2026

Zhou Chen, Qing Lili, Zou Tiantian, Zhao Ming, Guo Xinrui, Yin Wensa, Wang Jia, Lei Yinlei, Li Yinghan, Hu Liping, Liu Linlin, Nie Shengjie

Abstract excerpt

Objective: Depression is a heterogeneous psychiatric disorder and a growing public health concern, characterized by its high prevalence, recurrence rate, and association with suicide. There is evidence suggesting that both genetic susceptibility and environmental factors can regulate gene expression through DNA methylation, thereby influencing the occurrence and development of depression. The olfactory sensory...

Read the complete abstract on PubMed

Topics

Humans
DNA Methylation
Male
Female
Adult
CpG Islands
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Depression

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42723797
DOI: 10.3389/fneur.2026.1919737
PMCID: PMC13557989

Genes

OLFM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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