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Article

Integrated multi-omics identification of m6A-SNP-related diagnostic biomarkers in amyotrophic lateral sclerosis.

Frontiers in immunology - 1 Jan 2026

Wang Hongfen, Sun Bo, Wang Shiya, Pan Jing, Du Rongrong, Pang Xinyuan, Bai Jiongming, Han Jinming, Feng Jinli

Abstract excerpt

Background: Amyotrophic lateral sclerosis (ALS) lacks reliable and minimally invasive biomarkers for early diagnosis. m6A-associated single-nucleotide polymorphisms (m6A-SNPs) may influence RNA methylation and gene expression, offering opportunities to identify clinically relevant diagnostic markers. Methods: We integrated eQTLGen cis-eQTL data, RMVar m6A-SNP annotations, and ALS transcriptomic datasets to...

Read the complete abstract on PubMed

Topics

Humans
Amyotrophic Lateral Sclerosis
Polymorphism, Single Nucleotide
Biomarkers
Multiomics
RNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Quantitative Trait Loci

Epitranscriptome

Adenosine

Gene Expression Profiling

Genetic Predisposition to Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 42723774
DOI: 10.3389/fimmu.2026.1914869
PMCID: PMC13557987

Genes

FEM1C
SUZ12
BRI3
EIF2AK4
OXR1
TJAP1
TMED5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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