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Multi-hit genetic lesions and a stress-imprinted immune transcriptome define the inflammatory pathology in ALS patients

2026-07-10

Abstract excerpt

<title>Abstract</title> <p>Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative disease whose peripheral immune architecture remains incompletely defined. Here, we integrated whole-genome sequencing and single-cell RNA sequencing to define genomic and immune correlates of ALS. Genome-wide analysis of a monozygotic twin pair discordant for ALS pathology identified shared ALS-associa...

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Literature Corpus work
94ab607f-38ed-5353-bc44-bdcb04aac65c
DOI
10.21203/rs.3.rs-10046801/v1
Open publication

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Multi-hit genetic lesions and a stress-imprinted immune transcriptome define the inflammatory pathology in ALS patientsDOI 10.21203/rs.3.rs-10046801/v1
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