NS2A V89F mutation in a DENV1 clinical isolate enhances neurotropism and neuroinvasion.

doi:10.3389/fcimb.2026.1922765

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Article

NS2A V89F mutation in a DENV1 clinical isolate enhances neurotropism and neuroinvasion.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Zhao Yuqi, Wang Linqing, Lin Yifan, Chen Yangyang, Zhan Yan, Xi Kexin, Liu Yingfang, Shen Chenguang, Zhang Bao, Xiao Weiwei, Wu Qinghua, Zhu Li, Zhao Wei, Yang Fan, Gong Weijin, Lu Yuntao, Yu Jianhai

Abstract excerpt

Introduction: Dengue virus (DENV) neurological complications are increasingly reported, yet the viral genetic determinants of neurotropism remain poorly characterized. Methods: We screened 25 DENV1 clinical isolates from the 2014 outbreak in Guangdong, China, for neurotropism in suckling mice, and integrated comparative genomics, pre-expression functional assays, population-scale sequence analysis, and OpenFold3...

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Topics

Dengue Virus
Animals
Humans
Mice
Viral Nonstructural Proteins
Dengue

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Virus Replication

Viral Tropism

Mutation

Endothelial Cells

Genome, Viral

Brain

Mutation, Missense

Source

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Identifiers

PMID: 42718655
DOI: 10.3389/fcimb.2026.1922765
PMCID: PMC13553272

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