Article
Impact of BCL-2 rs2279115 and rs3943258 variants on protein expression and clinical outcome of urothelial bladder carcinoma.
Molecular biology reports - 7 Sept 2026
Kawasaki Julia Ayumi Ikeda, de Souza Ariane Pereira, Pontes João Pedro Rocha, Serpeloni Juliana Mara, de Oliveira Janaina Nicolau, Vanzela André Luís Laforga, Terziotti Fernando, Martinez-Lopez Wilner, de Oliveira Karen Brajão, Guembarovski Roberta Losi
Abstract excerpt
BACKGROUND: Urothelial bladder carcinoma (UBC) is the ninth most common malignancy worldwide and ranks thirteenth in cancer-related mortality. A significant challenge in managing non-muscle-invasive UBC (NMIBC) is the high recurrence rate, compounded by a paucity of robust prognostic biomarkers. Given that evasion of apoptosis is a hallmark of carcinogenesis, the apoptosis regulator BCL-2 oncogene plays a...
Read the complete abstract on PubMedTopics
- Humans
- Proto-Oncogene Proteins c-bcl-2
- Female
- Male
- Urinary Bladder Neoplasms