Article
TGFB1 and TGFBR1 polymorphic variants in relationship to bladder cancer risk and prognosis.
International journal of cancer - 1 Feb 2009
Castillejo Adela, Rothman Nathaniel, Murta-Nascimento Cristiane, Malats Núria, García-Closas Montserrat, Gómez-Martínez Angeles, Lloreta Josep, Tardón Adonina, Serra Consol, García-Closas Reina, Chanock Stephen, Silverman Debra T, Dosemeci Mustafa, Kogevinas Manolis, Carrato Alfredo, Soto José Luis, Real Francisco X
Abstract excerpt
The transforming growth factor-beta (TGF-beta) signalling pathway plays an important role in tumor development and progression. We aimed at analyzing whether 7 different common variants in genes coding for 2 key members of the TGF-beta signalling pathway (TGFB1 and TGFBR1) are associated with bladder cancer risk and prognosis. A total of 1,157 cases with urothelial cell carcinoma of the bladder and 1,157 matched...
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