Agrimol B induces autophagic death in TP53-mutant pancreatic cancer by targeting the S100A6-HDAC2-mutant p53 acetylation axis.

doi:10.1016/j.phymed.2026.158760

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Article

Agrimol B induces autophagic death in TP53-mutant pancreatic cancer by targeting the S100A6-HDAC2-mutant p53 acetylation axis.

Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Nov 2026

Xu Rui, Xia Liuyuan, Zhou Wei, Chen Xin, Jiang Yixin, Yan Yue, Xiong Qingyi, Lu Dong, Chen Hongzhuan, Wu Tong, Jin Jinmei, Zhang Weidong, Luan Xin

Abstract excerpt

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) harbors TP53 mutations at high frequency, yet therapeutic strategies that specifically target mutant p53 remain limited. PURPOSE: This study aimed to identify S100A6, a calcium-binding protein frequently upregulated in TP53-mutant PDAC, as a critical regulator of mutant p53 stability and tumor progression, and to explore potential S100A6-targeting agents for...

Read the complete abstract on PubMed

Topics

Humans
Tumor Suppressor Protein p53
Acetylation
Pancreatic Neoplasms
Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

S100 Calcium Binding Protein A6

Autophagy

Histone Deacetylase 2

Mutation

Animals

Carcinoma, Pancreatic Ductal

Cell Cycle Proteins

Source

Open in PubMed

Identifiers

PMID: 42700714
DOI: 10.1016/j.phymed.2026.158760

Genes

S100A6
TP53
HDAC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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