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Article

The role of ferroptosis in juvenile idiopathic arthritis: Causal inference and mediation by immune phenotypes.

Medicine - 4 Sept 2026

Yang Chun-Wu, Pan Xiu-Hua, Wang Ji-Gan

Abstract excerpt

This study employed a bidirectional 2-step, two-sample Mendelian randomization approach to investigate the causal relationships between ferroptosis-related genes and juvenile idiopathic arthritis (JIA) and to explore the mediating role of immune cells. Ferroptosis genes were identified from the deCODE database and matched with protein quantitative trait locus data as exposures to evaluate their causal effects on...

Read the complete abstract on PubMed

Topics

Arthritis, Juvenile
Humans
Ferroptosis
Phenotype
Genome-Wide Association Study
Quantitative Trait Loci
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 42700015
DOI: 10.1097/MD.0000000000050515
PMCID: PMC13549599

Genes

BID
CTSB
DECR1
DPP4
HSPB1
LIFR
PIEZO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 26 Oct 2026.

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