Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ferroptosis as a mediator of gut microbiota-driven inflammatory bowel disease: Evidence from genetic analyses.

Medicine - 6 Feb 2026

Xu Xinxin, Ye Hongyu, Ren Qingwei, Shao Xuejun, Wang Jianlong, Shi Ying, Du Yueting

Abstract excerpt

Gut microbiota dysbiosis is increasingly recognized as a contributor to inflammatory bowel disease (IBD), yet causal relationships and underlying mechanisms remain unclear. Ferroptosis, an iron-dependent form of regulated cell death, plays a key role in epithelial barrier damage and inflammation. This study aimed to determine whether specific gut microbial taxa are causally associated with IBD and whether...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dysbiosis
Share to Ferroptosis
Share to Gastrointestinal Microbiome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MUC1 gene

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Inflammatory Bowel Diseases

Share to Mendelian Randomization Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 41650031
DOI: 10.1097/MD.0000000000047614
PMCID: PMC12885656

Genes

IDO1
ADAM23
GPX4
MUC1
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ferroptosis as a mediator of gut microbiota-driven inflammatory bowel disease: Evidence from genetic analyses.PMID 41650031Read ↗

Bifidobacterium breve Promotes the Pathogenesis of IBS by Downregulating the Expression of Ferroptosis-Related Molecule ERBB1: A Mendelian Randomization Mediation Analysis.Semantic proximity Read ↗

Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants.Semantic proximity Read ↗

Assessment of Causal Direction Between Gut Microbiota and Inflammatory Bowel Disease: A Mendelian Randomization AnalysisSemantic proximity Read ↗

Exploring the intestinal ecosystem: from gut microbiota to associations with subtypes of inflammatory bowel diseaseSemantic proximity Read ↗

Two-Sample Mendelian Randomization Analysis Investigates Causal Associations Between Gut Microbial Genera and Inflammatory Bowel Disease, and Specificity Causal Associations in Ulcerative Colitis or Crohn’s DiseaseSemantic proximity Read ↗

The Role of Ferroptosis in Inflammatory Bowel Disease: Mechanisms and Therapeutic ImplicationsSemantic proximity Read ↗

Causal Mediation Role of Immune Cells in Gut Microbiota-Pneumonia Associations: A Mendelian Randomisation Study.Semantic proximity Read ↗

Genetically predicted immune cells mediate the association between gut microbiota and autoimmune liver diseasesSemantic proximity Read ↗

Exploring the causal relationship between gut microbiota and atopic dermatitis: A Mendelian randomization studySemantic proximity Read ↗

Gut microbiota and interstitial cystitis: exploring the gut-bladder axis through mendelian randomization, biological annotation and bulk RNA sequencing.Semantic proximity Read ↗

Investigating causal relationships between the gut microbiota and inflammatory skin diseases: A Mendelian randomization studySemantic proximity Read ↗

Genetic liability of gut microbiota for idiopathic pulmonary fibrosis and lung function: a two-sample Mendelian randomization study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.