Article
Identifying genetic risk factors for serious adverse drug reactions: current progress and challenges.
Nature reviews. Drug discovery - 1 Nov 2007
Wilke Russell A, Lin Debbie W, Roden Dan M, Watkins Paul B, Flockhart David, Zineh Issam, Giacomini Kathleen M, Krauss Ronald M
Abstract excerpt
Serious adverse drug reactions (SADRs) are a major cause of morbidity and mortality worldwide. Some SADRs may be predictable, based upon a drug's pharmacodynamic and pharmacokinetic properties. Many, however, appear to be idiosyncratic. Genetic factors may underlie susceptibility to SADRs and the identification of predisposing genotypes may improve patient management through the prospective selection of...
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