Article
Genetic association of zinc transporter 8 (ZnT8) autoantibodies in type 1 diabetes cases.
Diabetologia - 1 Jul 2012
Howson J M M, Krause S, Stevens H, Smyth D J, Wenzlau J M, Bonifacio E, Hutton J, Ziegler A G, Todd J A, Achenbach P
Abstract excerpt
AIMS/HYPOTHESIS: Autoantibodies to zinc transporter 8 (ZnT8A) are associated with risk of type 1 diabetes. Apart from the SLC30A8 gene itself, little is known about the genetic basis of ZnT8A. We hypothesise that other loci in addition to SLC30A8 are associated with ZnT8A. METHODS: The levels of ZnT8A were measured in 2,239 British type 1 diabetic individuals diagnosed before age 17 years, with a median duration...
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