Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antigenicity and epitope specificity of ZnT8 autoantibodies in type 1 diabetes.

Scandinavian journal of immunology - 1 Jan 2013

Skärstrand H, Lernmark A, Vaziri-Sani F

Abstract excerpt

The single nucleotide polymorphism (SNP) rs13266634 encodes either an Arginine (R) or a Tryptophan (W) (R325W) at the amino acid position 325 in the Zinc Transporter 8 (ZnT8) protein. Autoantibodies (Ab) that recognize ZnT8R, ZnT8W or both at the polymorphic site are common in newly diagnosed type 1 diabetes (T1D) patients. The epitope specificity and affinity of ZnT8Ab are poorly understood, but may be of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Affinity
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoantigens

Share to Cation Transport Proteins

Share to Epitopes, B-Lymphocyte

Share to Immunity, Humoral

Share to Peptide Fragments

Share to Zinc Transporter 8

Source

Identifiers

PMID: 23126564
DOI: 10.1111/sji.12008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antigenicity and epitope specificity of ZnT8 autoantibodies in type 1 diabetes.PMID 23126564Read ↗

A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.Semantic proximity Read ↗

A novel triple mix radiobinding assay for the three ZnT8 (ZnT8-RWQ) autoantibody variants in children with newly diagnosed diabetes.Semantic proximity Read ↗

Association between anti-ZnT8 autoantibody specificities and SLC30A8 Arg325Trp variant in Japanese patients with type 1 diabetes.Semantic proximity Read ↗

Human type 1 diabetes is associated with T cell autoimmunity to zinc transporter 8.Semantic proximity Read ↗

Autoantibodies to zinc transporter 8 and SLC30A8 genotype stratify type 1 diabetes risk.Semantic proximity Read ↗

Correlations between islet autoantibody specificity and the SLC30A8 genotype with HLA-DQB1 and metabolic control in new onset type 1 diabetes.Semantic proximity Read ↗

Zinc transporter 8 autoantibodies in patients with type 1 diabetes from a multiethnic population and their first degree relatives.Semantic proximity Read ↗

Detection and characterization of ZnT8 autoantibodies could help to screen latent autoimmune diabetes in adult-onset patients with type 2 phenotype.Semantic proximity Read ↗

Importance of Zinc Transporter 8 Autoantibody in the Diagnosis of Type 1 Diabetes in Latin Americans.Semantic proximity Read ↗

A mutagenesis study of autoantigen optimization for potential T1D vaccine designSemantic proximity Read ↗

Highly specific monoclonal antibodies for allosteric inhibition and immunodetection of the human pancreatic zinc transporter ZnT8.Semantic proximity Read ↗

Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.