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Article

A common nonsynonymous single nucleotide polymorphism in the SLC30A8 gene determines ZnT8 autoantibody specificity in type 1 diabetes.

Diabetes - 1 Oct 2008

Wenzlau Janet M, Liu Yu, Yu Liping, Moua Ong, Fowler Kimberly T, Rangasamy Sampathkumar, Walters Jay, Eisenbarth George S, Davidson Howard W, Hutton John C

Abstract excerpt

OBJECTIVE: Zinc transporter eight (SLC30A8) is a major target of autoimmunity in human type 1A diabetes and is implicated in type 2 diabetes in genome-wide association studies. The type 2 diabetes nonsynonymous single nucleotide polymorphism (SNP) affecting aa(325) lies within the region of highest ZnT8 autoantibody (ZnT8A) binding, prompting an investigation of its relationship to type 1 diabetes. RESEARCH...

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Identifiers

PMID: 18591387
DOI: 10.2337/db08-0522
PMCID: PMC2551679

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Source receipt: pubmed, retrieved 7 Sept 2026.

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