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Article

Genetics of Immune Dysregulation and Cancer Predisposition: Two Sides of the Same Coin.

Clinical and experimental immunology - 15 Dec 2022

Matza Porges Sigal, Shamriz Oded

Abstract excerpt

Approximately 10% of cancers have a hereditary predisposition. However, no genetic diagnosis is available in 60%-80% of familial cancers. In some of these families, immune dysregulation-mediated disease is frequent. The immune system plays a critical role in identifying and eliminating tumors; thus, dysregulation of the immune system can increase the risk of developing cancer. This review focuses on some of the...

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Identifiers

PMID: 36165533
DOI: 10.1093/cei/uxac089
PMCID: PMC9750831

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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