Article
Phenome-wide analyses identify an association between the parent-of-origin effects dependent methylome and the rate of aging in humans.
Genome biology - 15 May 2023
Gao Chenhao, Amador Carmen, Walker Rosie M, Campbell Archie, Madden Rebecca A, Adams Mark J, Bai Xiaomeng, Liu Ying, Li Miaoxin, Hayward Caroline, Porteous David J, Shen Xueyi, Evans Kathryn L, Haley Chris S, McIntosh Andrew M, Navarro Pau, Zeng Yanni
Abstract excerpt
BACKGROUND: The variation in the rate at which humans age may be rooted in early events acting through the genomic regions that are influenced by such events and subsequently are related to health phenotypes in later life. The parent-of-origin-effect (POE)-regulated methylome includes regions enriched for genetically controlled imprinting effects (the typical type of POE) and regions influenced by environmental...
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