Detection of FGFR Alterations in Urothelial Carcinoma: Current Diagnostic Methodologies, Technical Considerations and Future Perspectives.

doi:10.1016/j.clgc.2026.102644

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Article

Detection of FGFR Alterations in Urothelial Carcinoma: Current Diagnostic Methodologies, Technical Considerations and Future Perspectives.

Clinical genitourinary cancer - 1 Oct 2026

Ricciardi Gabriele, Ballato Mariagiovanna, Tralongo Pietro, Fiorentino Vincenzo, Zuccalà Valeria, Fadda Guido, Martini Maurizio

Abstract excerpt

Fibroblast growth factor receptor (FGFR) alterations have emerged as clinically actionable biomarkers in urothelial carcinoma (UC), particularly following the introduction of FGFR-targeted therapies for patients with advanced disease. Activating mutations, gene fusions, copy number alterations, and expression changes involving FGFR2 and, especially, FGFR3 contribute to urothelial tumorigenesis through persistent...

Read the complete abstract on PubMed

Topics

Humans
Biomarkers, Tumor
Liquid Biopsy
Mutation
Receptor, Fibroblast Growth Factor, Type 3

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Receptors, Fibroblast Growth Factor

Urinary Bladder Neoplasms

High-Throughput Nucleotide Sequencing

Carcinoma, Transitional Cell

Urologic Neoplasms

Quinoxalines

Receptor, Fibroblast Growth Factor, Type 2

Pyrazoles

Source

Open in PubMed

Identifiers

PMID: 42659728
DOI: 10.1016/j.clgc.2026.102644

Genes

FGFR2
FGFR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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