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Article

FGFR1/3 Signaling as an Achilles' Heel of Phenotypic Diversity in Urothelial Carcinoma.

European urology oncology - 1 Apr 2026

Pichler Renate, van Creij Nils C H, Mertens Laura S, Del Giudice Francesco, Koll Florestan, Soria Francesco, Subiela José Daniel, Plage Henning, Tymoszuk Piotr, Mayr Roman, Klinglmair Gerald, Seeber Andreas, Pichler Martin, Günther Michael, Ormanns Steffen, Compérat Eva, Li Roger, Moschini Marco, Pradére Benjamin

Abstract excerpt

FGFR inhibitors are a new therapeutic option for urothelial carcinoma (UC) with FGFR2/3 alterations. In this study, we analyzed genetic alterations, co-regulation, and differential expression for 45 genes encoding FGF, FGFR, or FGF-binding proteins (FGFBPs) in five published UC cohorts (n = 3939 MIBC) and 39 UC cell lines (DepMap portal). Network analyses identified FGFR1/3 genes as critical oncogenic hubs,...

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Share to Carcinoma, Transitional Cell
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptor, Fibroblast Growth Factor, Type 1

Share to Receptor, Fibroblast Growth Factor, Type 2

Share to Receptor, Fibroblast Growth Factor, Type 3

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Share to Urinary Bladder Neoplasms

Source

Identifiers

PMID: 40716983
DOI: 10.1016/j.euo.2025.07.005

Genes

FGFR1
FGFR3
FGFR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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